Target pattern-dependent emotional processing in hippocampal circuits

Brisbane Convention & Exhibition Centre 

The hippocampus is an evolutionarily conserved brain structure in vertebrate species and is critical for memory, cognition, stress and emotion. It comprises subregions including dentate gyrus (DG), cornu ammonis (CA) fields and subicular complex. The ventral hippocampus is widely connected with brain areas in the thalamus, hypothalamus, amygdala and prefrontal cortex, and plays crucial roles in the emotional processing for rewards and punishments. By leveraging the power of single-neuron projectome analysis, we have characterized the target pattern of distinct projectome cell types in the thalamo-hippocampal circuit, and identified specific functions of these cell types and circuits in the emotional processing including fear memory generalization.