Decoding The Brain: Modelling Neural Dynamics to Improve Brain Stimulation

The brain comprises complex neuronal networks that underlie its adaptive and versatile functionality. Recent neurotechnological innovations have dramatically expanded our ability to investigate these networks, enabling precise interventions at the microcircuit level. Here, I present modelling research examining how targeted perturbations of excitatory and inhibitory neurons within microcircuits can illuminate neural dynamics. Subsequently, I introduce novel models for decoding neural activity across larger scales. Based on these modelling work, I argue that effectively connecting microscale and macroscale neural phenomena requires more sophisticated computational models for encoding and decoding brain activity. Technological advances are necessary, but they must be complemented by robust theoretical frameworks that can translate insights from localised neural interactions to system-wide neural processes.