Highly structured global brain activity and its functional relevance

The presentation will focus on infra-slow global brain activity, reviewing its various forms across spatial scales and species, along with evidence of its potential relevance to various brain functions. Specifically, I will review the infra-slow global brain activity measured using various modalities in species: from micro-level neuronal recordings from mice, to meso-level local field potential (LFP) from monkeys, and macro-level fMRI signals in humans. Furthermore, I will discuss evidence linking this global brain activity to seconds-scale arousal fluctuations, “offline” memory processes, “online” sensory processing and memory functions, as well as its potential role in brain waste clearance in neurodegenerative diseases.