Benchmarking methods for mapping functional connectivity in the brain

FC is a statistical construct and its operational definition is largely arbitrary. Inter-regional functional interactions in the brain extend far beyond commonly used zero-lag Pearson's correlations. In this talk, we will present a comprehensive investigation on the topological and geometric organization, neurobiological associations, and cognitive-behavioral relevance using 239 pairwise interaction statistics, based on MR, MEG and PET imaging. We highlight the importance of tailoring a pairwise statistic to a specific neurophysiological mechanism and research question. https://www.biorxiv.org/content/10.1101/2024.05.07.593018v1