Altered Hierarchical Organization of the Brain in Young-Onset Alzheimer’s Disease

Brisbane Convention & Exhibition Centre 

Young-onset Alzheimer's Disease is a rare form of Alzheimer's Disease characterized by early symptom onset (< 65 years) and more aggressive clinical course (Mendez, 2019). Previous literature reported altered connectivity within the default-mode network in patients with young-onset Alzheimer's Disease (Gour et al., 2014; Lehmann et al., 2013; Singh et al., 2023), which is a large-scale brain network associated with episodic memory and self-awareness (Buckner et al., 2005). Despite the importance of the default-mode network in Alzheimer's Disease pathology and cognitive functioning, little is known about how the default-mode network interacts with other cognitive networks, such as salience and dorsal attention network, in patients with young-onset Alzheimer's Disease.