Aging Minds: Molecular and Functional Pathways of Cognitive Decline

Brisbane Convention & Exhibition Centre 

During this talk, I will present results from from the DyNAMiC study, with a specific emphasis on the functional dynamics and the neurotransmitter dopamine. I’ll present compelling evidence that delineates distinct phases of age-related reductions in D1-like dopamine receptors (D1DR) across the adult lifespan. Subsequently, I'll discuss the consequences of declining D1DR levels on brain functional dynamics across various scales, including regional and network scales, and outline their impacts on cognitive decline. Together, these studies will provide insights into the molecular and functional mechanisms of cognitive decline in aging.