Alessandro Gozzi, PhD - Mechanism of functional (dys)connectivity

Brisbane Convention & Exhibition Centre 

Human brain disorders are characterized by dysfunctional communication among brain regions. Yet, the biological mechanisms underlying this "functional dysconnectivity" remain unclear. In my talk, I will highlight recent cross-species research aimed at decoding patterns of brain dysconnectivity into their molecular and neurophysiological underpinnings. In particular, I will illustrate how targeted perturbational approaches can reveal fundamental physiological principles underlying the organization of large-scale functional connectivity, and its disruption in brain disorders. By bridging findings across species and investigational scales, this emerging approach opens new avenues for modelling and interpreting functional connectivity in both healthy and in neuropathological states.